Pyridine → HCID 59774860、化合物

HRID 2422528ノート

反応式

HRID 2422528 の反応式
[CH:1]([C:3]1[CH:12]=[C:11]2[C:6]([C:7]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[CH:8][C:9]([C:13]#[N:14])=[N:10]2)=[CH:5][CH:4]=1)=O.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[N:40]1C=CC=CC=1.[N:46](C(OC(C)C)=O)=[N:47]C(OC(C)C)=O>C1(C)C=CC=CC=1.[Zn](N=[N+]=[N-])N=[N+]=[N-]>[N:40]([CH2:1][C:3]1[CH:12]=[C:11]2[C:6]([C:7]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[CH:8][C:9]([C:13]#[N:14])=[N:10]2)=[CH:5][CH:4]=1)=[N+:46]=[N-:47]

参加物

7

反応物 4

HCID 1049PyridineHCID 11776TriphenylphosphineHCID 75555Diisopropyl diazene-1,2-dicarboxylateHCID 574378457-Formyl-4-phenylquinoline-2-carbonitrile

生成物 1

HCID 59774860HCID 59774860、化合物

試薬・触媒・溶媒 2

HCID 178514646Zinc azide触媒HCID 1140Toluene溶媒

実験手順

To a solution of 7-formyl-4-phenylquinoline-2-carbonitrile (520 mg, 2.0 mmol) in toluene (12 mL) was added triphenylphosphine (1.05 g, 4.0 mmol), Zn(N3)2.2 pyridine (461 mg, 1.5 mmol) and diisopropyl azodicarboxylate (787 μL, 4.0 mmol). The mixture was stirred at room temperature for 3 h, concentrated and purified on silica gel (eluting with EtOAc/hexanes, 3:7) to give the title compound. MS (+ESI): 286 (M+H)+.

後処理

  1. concentrationconcentrated
  2. custompurified on silica gel (eluting with EtOAc/hexanes, 3:7)

出典と根拠

ORDレコード
ord-72e34ae5440f4cb79bb8595cbda265bb
出典データセット
uspto-grants-2011_06
特許番号
US07960409B2

反応ノート

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