Imidazole → ethyl 2-(1H-imidazol-1-yl)acetate

HRID 242258ノート

反応式

HRID 242258 の反応式
[Na].[NH:2]1[CH:6]=[CH:5][N:4]=[CH:3]1.Br[CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10]>C(O)C>[CH2:12]([O:11][C:9](=[O:10])[CH2:8][N:2]1[CH:6]=[CH:5][N:4]=[CH:3]1)[CH3:13]

参加物

5

反応物 3

HCID 795ImidazoleHCID 7748Ethyl bromoacetateHCID 5360545Sodium

生成物 1

HCID 3798501ethyl 2-(1H-imidazol-1-yl)acetate

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

118.2 g (5.1 mol) sodium are slowly added to 2.5 liters ethanol. 350.0 g (5.1 mol) imidazole are then added and 570 ml (858.6 g, 5.1 mol) ethyl bromoacetate are added dropwise at an internal temperature of 20-25° C. The mixture is stirred at RT for 24 h. The solid which has precipitated out is filtered off, the ethanol is removed in vacuo and the mixture is filtered again. The residue is purified by column chromatography over silica gel (mobile phase: ethyl acetate).

後処理

  1. customThe solid which has precipitated out
  2. filtrationis filtered off
  3. customthe ethanol is removed in vacuo
  4. filtrationthe mixture is filtered again
  5. customThe residue is purified by column chromatography over silica gel (mobile phase: ethyl acetate)

出典と根拠

ORDレコード
ord-18f996ed93524ea7b83dd37ad0a09225
出典データセット
uspto-grants-2014_02
特許番号
US08653111B2

反応ノート

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