4-Aminobenzoic Acid → 3-Methyl-2-[4-(3-piperidin-1-ylpropoxy)phenyl]pyrido[2,3-d]-pyrimidin-4(3h)-one

HRID 2422589

反応式

HRID 2422589 の反応式
[CH:1]1[C:6]([C:7](O)=O)=[CH:5][CH:4]=[C:3](N)[CH:2]=1.[N:11]1([CH2:17][CH2:18][CH2:19][O:20]C2C=CC(C=O)=CC=2)[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1.[N:29]1([CH2:34][CH2:35][CH2:36][O:37]C2C=CC(C=O)=CC=2)[CH2:33][CH2:32][CH2:31]C1.C1([N:51]2[CH2:56]CC(OC3C=CC(C=O)=CC=3)CC2)CCCC1.C1([N:70]2CCC(OC3C=CC(C=O)=CC=3)CC2)CCC1.C1(N2CCC(OC3C=CC(C=O)=C(OC)C=3)CC2)CCCC1.C1(N2CCC(OC3C=CC(C=O)=C(OC)C=3)CC2)CCC1.C1(N2CCC(OC3C=CC(C=O)=CN=3)CC2)CCC1.C1(N2CCC(OC3N=CC(C=O)=CN=3)CC2)CCC1.C[C@H]1CCCN(CCCOC2C=CC(C=O)=CC=2)C1>>[CH3:56][N:51]1[C:36](=[O:37])[C:35]2[CH:31]=[CH:32][CH:33]=[N:29][C:34]=2[N:70]=[C:7]1[C:6]1[CH:1]=[CH:2][C:3]([O:20][CH2:19][CH2:18][CH2:17][N:11]2[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]2)=[CH:4][CH:5]=1

参加物

11

反応物 10

HCID 9784-Aminobenzoic AcidHCID 27663244-(3-Piperidin-1-ylpropoxy)benzaldehydeHCID 73793404-{3-[(3S)-3-methylpiperidin-1-yl]propoxy}benzaldehydeHCID 116515734-(3-Pyrrolidin-1-ylpropoxy)benzaldehydeHCID 860848044-[(1-Cyclopentylpiperidin-4-yl)oxy]-2-methoxybenzaldehydeHCID 866244604-[(1-Cyclopentyl-4-piperidinyl)oxy]benzaldehydeHCID 866244614-[(1-Cyclobutyl-4-piperidinyl)oxy]benzaldehydeHCID 866244624-[(1-Cyclobutylpiperidin-4-yl)oxy]-2-methoxybenzaldehydeHCID 866244636-[(1-Cyclobutylpiperidin-4-yl)oxy]nicotinaldehydeHCID 866244652-[(1-Cyclobutylpiperidin-4-yl)oxy]pyrimidine-5-carbaldehyde

生成物 1

HCID 116394693-Methyl-2-[4-(3-piperidin-1-ylpropoxy)phenyl]pyrido[2,3-d]-pyrimidin-4(3h)-one

実験手順

Compounds of Examples 16 to 59 can be produced according to the method of Example 15 or a method similar to it or a combination of the method with an ordinary method, but starting from the corresponding aminobenzoic acid, amine and separately prepared aromatic aldehydes such as 4-(3-piperidin-1-ylpropoxy)benzaldehyde, 4-(3-pyrrolidin-1-ylpropoxy)benzaldehyde, 4-[(1-cyclopentyl-4-piperidinyl)oxy]benzaldehyde, 4-[(1-cyclobutyl-4-piperidinyl)oxy]benzaldehyde, 4-[(1-cyclopentylpiperidin-4-yl)oxy]-2-methoxybenzaldehyde, 4-[(1-cyclobutylpiperidin-4-yl)oxy]-2-methoxybenzaldehyde, 6-[(1-cyclobutylpiperidin-4-yl)oxy]nicotinaldehyde, 2-[(1-cyclobutylpiperidin-4-yl)oxy]pyrimidine-5-carbaldehyde, 4-{3-[(3S)-3-methylpiperidin-1-yl]propoxy}benzaldehyde.

出典と根拠

ORDレコード
ord-4e79d52b8f524476a39c9c47a8fc7d55
出典データセット
uspto-grants-2011_06
特許番号
US07960394B2

関連ノート

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