L-Leucine, N-((1,1-dimethylethoxy)carbonyl)- → HCID 71105111、化合物

HRID 242387

反応式

HRID 242387 の反応式
[OH:1][CH2:2][C:3]1[N:4]=[C:5]([C:16](=[O:18])[CH3:17])[N:6]([CH2:8][O:9][CH2:10][CH2:11][Si:12]([CH3:15])([CH3:14])[CH3:13])[CH:7]=1.[NH:19]([C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])[C@H:20]([C:25]([OH:27])=O)[CH2:21][CH:22]([CH3:24])[CH3:23].CCN=C=N[CH2:40][CH2:41][CH2:42]N(C)C.Cl>ClCCl.CN(C1C=CN=CC=1)C>[C:16]([C:5]1[N:6]([CH2:8][O:9][CH2:10][CH2:11][Si:12]([CH3:14])([CH3:13])[CH3:15])[CH:7]=[C:3]([CH2:2][O:1][C:25](=[O:27])[C@@H:20]([NH:19][C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])[CH2:21][C:22]2[CH:23]=[CH:42][CH:41]=[CH:40][CH:24]=2)[N:4]=1)(=[O:18])[CH3:17]

参加物

6

反応物 3

HCID 83170L-Leucine, N-((1,1-dimethylethoxy)carbonyl)-HCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 710869721-(4-hydroxymethyl-1-(2-trimethylsilylethoxymethyl)-1H-imidazol-2-yl)ethanone

生成物 1

HCID 71105111HCID 71105111、化合物

試薬・触媒・溶媒 2

HCID 142844-(Dimethylamino)pyridine触媒HCID 6344Dichloromethane溶媒

実験手順

The compound (2.00 g) obtained in (3) was dissolved in dichloromethane (10 mL), and Boc-Leu-OH (2.21 g), EDC.HCl (2.13 g), and DMAP (0.99 g) were added while stirring. After the stirring was continued for 1 day, the solvent was distilled off under reduced pressure. The resulting residue was purified by flash chromatography (ethyl acetate/chloroform=0%→25%) using silica gel column (product name: Hi-Flash Column 3 L, manufactured by Yamazen Corporation) to afford the title compound (3.20 g).

後処理

  1. distillationthe solvent was distilled off under reduced pressure
  2. customThe resulting residue was purified by flash chromatography (ethyl acetate/chloroform=0%→25%)

出典と根拠

ORDレコード
ord-ee60c6e8bc1744969018dda8e777ca7c
出典データセット
uspto-grants-2014_02
特許番号
US08653126B2

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