Sodium Carbonate → (3,5-Difluoro-phenyl)-phenyl-methanone oxime
反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:13]=[C:14]([F:16])[CH:15]=1)[C:5]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)=O.Cl.[NH2:18][OH:19].C(=O)([O-])[O-].[Na+].[Na+]>C(O)C>[F:1][C:2]1[CH:3]=[C:4]([C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[N:18][OH:19])[CH:13]=[C:14]([F:16])[CH:15]=1参加物
5
実験手順
To 3,5-difluorobenzophenone (2.5 g) in ethanol (30 mL) was added hydroxylamine hydrochloride (3 eq) and sodiumcarbonate (3 eq). The reaction mixture was stirred at reflux for 4 hours and then allowed to cool down to room temperature. The precipitate was then isolated by filtration and washed with water to yield the title compound as a white solid (m.p.=91-93° C., Yield=89%), reflux, 4 h
後処理
- temperatureat reflux for 4 hours
- customThe precipitate was then isolated by filtration
- washwashed with water
出典と根拠
- ORDレコード
- ord-aafbf2c0e8904d4faedfeee18313daf0
- 出典データセット
- uspto-grants-2011_06
- 特許番号
- US07964645B2
反応ノート
読み込み中…