Tetrahydrofuran → HCID 67248522、化合物

HRID 2425315ノート

反応式

HRID 2425315 の反応式
[CH2:1]=[CH:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].B1C2CCCC1CCC2.C1COCC1.[OH-].[Na+].Br[C:26]1[CH:27]=[C:28]2[C:32](=[CH:33][CH:34]=1)[C:31](=[O:35])[CH2:30][CH2:29]2>>[CH2:1]([C:26]1[CH:27]=[C:28]2[C:32](=[CH:33][CH:34]=1)[C:31](=[O:35])[CH2:30][CH2:29]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

参加物

6

反応物 5

HCID 8028TetrahydrofuranHCID 81251-OcteneHCID 14798Sodium HydroxideHCID 789669-Borabicyclo(3.3.1)nonaneHCID 5206955-Bromo-1-indanone

生成物 1

HCID 67248522HCID 67248522、化合物収率 95.3%

実験手順

A Boron complex was first created by adding 1-octene (0.744 g, 6.633 mmol) to a stirring solution of 0.5M 9-BBN in THF (13.27 mL, 6.633 mmol). The reaction was left to stir at room temperature overnight. 3M NaOH (2.34 mL) was then added to the stirring solution followed by the addition of 5-Bromo-indan-1-one (1 g, 4.7 mmol) and Pd(Ph3)4 (0.145 g, 0.126 mmol). The reaction was refluxed for twelve hours. The resulting solution was concentrated and purified using silica gel chromatography eluding with hexanes-EtOAc (9:1). The reaction provided 2 (1.094 g, 4.48 mmol, 95%) as a clear liquid.

後処理

  1. waitThe reaction was left
  2. temperatureThe reaction was refluxed for twelve hours
  3. concentrationThe resulting solution was concentrated
  4. custompurified

出典と根拠

ORDレコード
ord-928af27c7e1b4f4c9a9c6240b8d6e3e8
出典データセット
uspto-grants-2011_06
特許番号
US07964649B2

反応ノート

読み込み中…