Hydrochloric Acid → 5-Methylindolin-2-one
反応式
[CH3:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2=O.O.NN.Cl>>[CH3:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[CH2:5]2参加物
4
反応条件
- 温度
- 150 °C
実験手順
A mixture of 5-methylisatin (15.0 g) and 60 ml of hydrazine hydrate was stirred at 140-160° C. for 4 hours. The reaction mixture was cooled to room temperature, poured into 300 ml of ice water and acidified to pH 2 with 6 N hydrochloric acid. After standing at room temperature for 2 days, a precipitate formed which was collected by vacuum filtration, washed with water and dried under vacuum to give 6.5 g (47% yield) of 5-methyl-2-oxindole.
後処理
- temperatureThe reaction mixture was cooled to room temperature
- waitAfter standing at room temperature for 2 days
- customa precipitate formed which
- filtrationwas collected by vacuum filtration
- washwashed with water
- customdried under vacuum
出典と根拠
- ORDレコード
- ord-a4e1f14131e349d8b033754a9d3dbffd
- 出典データセット
- uspto-grants-2005_02
- 特許番号
- US06855730B2
反応ノート
読み込み中…