Hydrochloric Acid → 4-Methyl-1H-1,2,3-triazole-1-acetic acid

To a solution of 0.51 g (3.0 mmol) of ethyl [4-methyl-1H-1,2,3-triazole-1-yl]acetate from step B above in tetrahydrofuran (10 ml), methanol (6 ml) was added 6 mL (6 mmol) of an aqueous 1.0 M lithium hydroxide solution. The resulting mixture was stirred at ambient temperature for 1 h. The reaction mixture was neutralized with 8 mL of a 2 N hydrochloric acid solution which was then evaporated to remove all volatiles. The aqueous phase was extracted with ethyl acetate and the combined organics were washed with brine, dried over magnesium sulfate, filtered and evaporated to dryness to afford the title compound as a white solid (0.40 g, 95%). LC/MS 142 (M+1).

1. customwas then evaporated
2. customto remove all volatiles
3. extractionThe aqueous phase was extracted with ethyl acetate
4. washthe combined organics were washed with brine
5. dry with materialdried over magnesium sulfate
6. filtrationfiltered
7. customevaporated to dryness

ORDレコード

ord-9a2d257611d644ada5c9394f66aca693

出典データセット

uspto-grants-2014_02

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08653260B2