Hydrochloric Acid → 1,4-Dimethyl-1H-pyrazole-3-carboxylic acid

HRID 244687

反応式

HRID 244687 の反応式
[OH-].[Li+].C1COCC1.[CH3:8][N:9]1[CH:13]=[C:12]([CH3:14])[C:11]([C:15]([O:17]C)=[O:16])=[N:10]1.Cl>O>[CH3:8][N:9]1[CH:13]=[C:12]([CH3:14])[C:11]([C:15]([OH:17])=[O:16])=[N:10]1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 8028TetrahydrofuranHCID 20718566methyl 1,4-dimethyl-1H-pyrazole-3-carboxylate

生成物 1

HCID 53256851,4-Dimethyl-1H-pyrazole-3-carboxylic acid

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Lithium hydroxide (0.864 g), THF (30 ml) and water (30 ml) were added to methyl 1,4-dimethyl-1H-pyrazole-3-carboxylate (1.39 g) and the reaction was stirred at room temperature for 3 h. The reaction was acidified with 5M HCl (aq) to pH to 7 and then washed through a waters HLB OASIS cation exchange cartridge. The cartridge was preconditioned with methanol, then water. The reaction was loaded onto the cartridge and washed with water, then eluted with methanol. The methanol fraction was evaporated in vacuo to give title compound, 1.1 g.

後処理

  1. washwashed through a waters HLB OASIS cation exchange cartridge
  2. washwashed with water
  3. washeluted with methanol
  4. customThe methanol fraction was evaporated in vacuo

出典と根拠

ORDレコード
ord-96d268033c7b46709567f9bdc6904a32
出典データセット
uspto-grants-2014_02
特許番号
US08658635B2

関連ノート

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