Acetic Anhydride → L-Phenylalanine, methyl ester

HRID 24638

反応式

HRID 24638 の反応式
OC(C(F)(F)F)=O.[CH3:8][O:9][C:10](=[O:37])[C@H:11]([CH2:23][C:24]1[CH:29]=[CH:28][C:27](C2C=CC=CC=2N)=[CH:26][CH:25]=1)[NH:12]C(=O)C1C(Cl)=CC=CC=1Cl.CC(OC(C)=O)=O.CCN(C(C)C)C(C)C.CCOC(C)=O>C1COCC1>[CH3:8][O:9][C:10](=[O:37])[C@H:11]([CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[NH2:12]

参加物

6

反応物 4

HCID 7918Acetic AnhydrideHCID 8857Ethyl AcetateHCID 81531DiisopropylethylamineHCID 131723775N-(2,6-dichlorobenzoyl)-4-(2-aminophenyl)-L-phenylalanine methyl ester TFA salt

生成物 1

HCID 736234L-Phenylalanine, methyl ester

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

N-(2,6-Dichlorobenzoyl)-4-(2-aminophenyl)-L-phenylalanine methyl ester TFA salt (90 mg) was dissolved in dry THF (5 mL). Ac2O (60 μL) and DIEA (160 μL) were added and the mixture was stirred at room temperature for 12 h. EtOAc was added and the resulting mixture was extracted with water. The organic phase was dried (MgSO4) and evaporated to give N-(2,6-dichlorobenzoyl)-4-[2-(acetylamino)]phenyl]-L-phenylalanine methyl ester.

後処理

  1. extractionthe resulting mixture was extracted with water
  2. dry with materialThe organic phase was dried (MgSO4)
  3. customevaporated

出典と根拠

ORDレコード
ord-1434c017a5c64fb6b877dce0c0b7ee4c
出典データセット
uspto-grants-2005_02
特許番号
US06855843B2

関連ノート

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