Thiomorpholine → 4-(3,5-Dimethoxybenzyl)thiomorpholine
反応式
[NH:1]1[CH2:6][CH2:5][S:4][CH2:3][CH2:2]1.[CH3:7][O:8][C:9]1[CH:10]=[C:11]([CH:14]=[C:15]([O:17][CH3:18])[CH:16]=1)[CH2:12]Cl>C1COCC1>[CH3:18][O:17][C:15]1[CH:14]=[C:11]([CH2:12][N:1]2[CH2:6][CH2:5][S:4][CH2:3][CH2:2]2)[CH:10]=[C:9]([O:8][CH3:7])[CH:16]=1参加物
4
実験手順
Thiomorpholine (3.4 g) was added to a solution of 3,5-dimethoxybenzyl chloride (2 g) in THF (25 mL) and the mixture was stirred overnight at room temperature. The solid material was removed by filtration and the filtrate was evaporated. The residue was purified by column chromatography (silica gel; eluent: EtOAc/hexane 1/2) to yield 2 g of 3,5-dimethoxy-1-(thiomorpholino-methyl)benzene. ESMS: m/z 253 (M).
後処理
- customThe solid material was removed by filtration
- customthe filtrate was evaporated
- customThe residue was purified by column chromatography (silica gel; eluent: EtOAc/hexane 1/2)
出典と根拠
- ORDレコード
- ord-d8bd3fe4ea95445aa9547aebb5a6afed
- 出典データセット
- uspto-grants-2005_02
- 特許番号
- US06855843B2
反応ノート
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