Thiomorpholine → 4-(3,5-Dimethoxybenzyl)thiomorpholine

HRID 24706

反応式

HRID 24706 の反応式
[NH:1]1[CH2:6][CH2:5][S:4][CH2:3][CH2:2]1.[CH3:7][O:8][C:9]1[CH:10]=[C:11]([CH:14]=[C:15]([O:17][CH3:18])[CH:16]=1)[CH2:12]Cl>C1COCC1>[CH3:18][O:17][C:15]1[CH:14]=[C:11]([CH2:12][N:1]2[CH2:6][CH2:5][S:4][CH2:3][CH2:2]2)[CH:10]=[C:9]([O:8][CH3:7])[CH:16]=1

参加物

4

反応物 2

HCID 67164ThiomorpholineHCID 27583953,5-Dimethoxybenzyl chloride

生成物 1

HCID 7560214-(3,5-Dimethoxybenzyl)thiomorpholine収率 73.7%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Thiomorpholine (3.4 g) was added to a solution of 3,5-dimethoxybenzyl chloride (2 g) in THF (25 mL) and the mixture was stirred overnight at room temperature. The solid material was removed by filtration and the filtrate was evaporated. The residue was purified by column chromatography (silica gel; eluent: EtOAc/hexane 1/2) to yield 2 g of 3,5-dimethoxy-1-(thiomorpholino-methyl)benzene. ESMS: m/z 253 (M).

後処理

  1. customThe solid material was removed by filtration
  2. customthe filtrate was evaporated
  3. customThe residue was purified by column chromatography (silica gel; eluent: EtOAc/hexane 1/2)

出典と根拠

ORDレコード
ord-d8bd3fe4ea95445aa9547aebb5a6afed
出典データセット
uspto-grants-2005_02
特許番号
US06855843B2

関連ノート

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