3,5-Dichlorobenzaldehyde → O-Methyl-3,5-dichlorobenzaldoxime

HRID 247408

反応式

HRID 247408 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([Cl:10])[CH:9]=1)[CH:5]=O.Cl.[CH3:12][O:13][NH2:14]>C(O)C.N1C=CC=CC=1>[CH3:12][O:13][N:14]=[CH:5][C:4]1[CH:3]=[C:2]([Cl:1])[CH:9]=[C:8]([Cl:10])[CH:7]=1

参加物

5

反応物 2

HCID 357463,5-DichlorobenzaldehydeHCID 521874O-Methylhydroxylamine hydrochloride

生成物 1

HCID 72726781O-Methyl-3,5-dichlorobenzaldoxime収率 94%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 1049Pyridine溶媒

実験手順

A solution of 3,5-dichlorobenzaldehyde (0.0571 mol) and methoxyamine hydrochloride (0.0629 mol) in ethanol (50 ml) and pyridine (50 ml) was stirred 18 hours at room temperature. The reaction was concentrated and partitioned between methylene chloride and water. The organic phase was washed with 3N aqueous hydrogen chloride, dried over sodium sulfate and was concentrated to yield 10.9 g (94%) white solid, mp 53°.

後処理

  1. concentrationThe reaction was concentrated
  2. custompartitioned between methylene chloride and water
  3. washThe organic phase was washed with 3N aqueous hydrogen chloride
  4. dry with materialdried over sodium sulfate
  5. concentrationwas concentrated

出典と根拠

ORDレコード
ord-9fa7e3ca066a4f54be725bc7e4f90633
出典データセット
uspto-grants-1987_11
特許番号
US04707488

関連ノート

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