Pyridine → 1-Bromo-4-(chloromethyl)-2-methoxybenzene

HRID 247453ノート

反応式

HRID 247453 の反応式
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]O)=[CH:4][C:3]=1[O:10][CH3:11].N1C=CC=CC=1.S(Cl)([Cl:20])=O>C1(C)C=CC=CC=1.O>[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][Cl:20])=[CH:4][C:3]=1[O:10][CH3:11]

参加物

6

反応物 3

HCID 1049PyridineHCID 24386Thionyl ChlorideHCID 13551345(4-Bromo-3-methoxyphenyl)-methanol

生成物 1

HCID 201606681-Bromo-4-(chloromethyl)-2-methoxybenzene

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 1140Toluene溶媒

実験手順

4-Bromo-3-methoxybenzyl alcohol (21.7 g, 0.1 m) dissolved in toluene (200 ml) containing pyridine (11.8 g, 0.15 m) is stirred at 5° and treated wiih thionyl chloride (23.8 g, 0.2 m). The mixture is stirred, diluted with water and the organic layer washed with dilute hydrochloric acid, dried and concentrated in vacuo to give 4-bromo-3-methoxybenzyl chloride.

後処理

  1. stirringThe mixture is stirred
  2. washthe organic layer washed with dilute hydrochloric acid
  3. customdried
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-2b5d87918c484b3b8c5eb1f62f3d0379
出典データセット
uspto-grants-1987_11
特許番号
US04707483

反応ノート

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