2-tert-Butyl-6-methylphenol → 3-(3-Tert-butyl-4-hydroxy-5-methylphenyl)-1-n-dodecylpyrrolidine-2,5-dione

HRID 247612

反応式

HRID 247612 の反応式
[H-].[Na+].[C:3]([C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([CH3:13])[C:8]=1[OH:14])([CH3:6])([CH3:5])[CH3:4].[CH2:15]([N:27]1[C:31](=[O:32])[CH:30]=[CH:29][C:28]1=[O:33])[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26]>C(O)(C)(C)C>[C:3]([C:7]1[CH:12]=[C:11]([CH:30]2[CH2:29][C:28](=[O:33])[N:27]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[C:31]2=[O:32])[CH:10]=[C:9]([CH3:13])[C:8]=1[OH:14])([CH3:6])([CH3:5])[CH3:4]

参加物

5

反応物 3

HCID 166782-tert-Butyl-6-methylphenolHCID 24758Sodium hydrideHCID 871911H-Pyrrole-2,5-dione, 1-dodecyl-

生成物 1

HCID 141483773-(3-Tert-butyl-4-hydroxy-5-methylphenyl)-1-n-dodecylpyrrolidine-2,5-dione

試薬・触媒・溶媒 1

HCID 6386tert-Butanol溶媒

実験手順

This compound is prepared by the procedure of Example 1 from 1.20 g (50 mmol) of sodium hydride, 8.21 g (50 mmol) of 2-tert-butyl-6-methylphenol, and 13.27 g (50 mmol) of N-n-dodecylmaleimide in tert-butyl alcohol. The residue is purified by preparative HPLC (8:2 heptane:ethyl acetate eluent) to give 4.70 g (22%) of a yellow wax.

後処理

  1. customThe residue is purified by preparative HPLC (8:2 heptane:ethyl acetate eluent)
  2. customto give 4.70 g (22%) of a yellow wax

出典と根拠

ORDレコード
ord-f454d7b30ea141779d1e7812070e00b0
出典データセット
uspto-grants-1987_11
特許番号
US04709050

関連ノート

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