Ammonium nitrate → 1-Acetyl-5-nitroindolin-2-one

HRID 24796

反応式

HRID 24796 の反応式
[C:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6][C:5]1=[O:13])(=[O:3])[CH3:2].[N+:14]([O-])([O-:16])=[O:15].[NH4+]>S(=O)(=O)(O)O>[C:1]([N:4]1[C:12]2[C:7](=[CH:8][C:9]([N+:14]([O-:16])=[O:15])=[CH:10][CH:11]=2)[CH2:6][C:5]1=[O:13])(=[O:3])[CH3:2]

参加物

4

反応物 2

HCID 22985Ammonium nitrateHCID 3237191-Acetylindolin-2-one

生成物 1

HCID 28393291-Acetyl-5-nitroindolin-2-one

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒

実験手順

17.5 g (0.10 mol) of 1-acetyl-2-indolinone are dissolved in 100 ml of conc. sulphuric acid and at −10° C. 8.8 g (0.11 mol) of ammonium nitrate are added batchwise and stirred for 15 minutes. The reaction is poured onto ice water, suction filtered and washed with water. The residue is distributed in ethyl acetate/water, the combined organic extracts are dried and concentrated by evaporation.

後処理

  1. additionThe reaction is poured onto ice water, suction
  2. filtrationfiltered
  3. washwashed with water
  4. customthe combined organic extracts are dried
  5. concentrationconcentrated by evaporation

出典と根拠

ORDレコード
ord-876a4116b49845fd9885779f56dd4f70
出典データセット
uspto-grants-2005_02
特許番号
US06855710B2

関連ノート

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