Water → 3-Hexadecyloxy-2-methylenepropan-1-ol

HRID 248143

反応式

HRID 248143 の反応式
[H-].[Na+].C(O)[C:4]([OH:7])=[CH:5][CH3:6].[CH2:9](Br)[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24].O.CN(C)[CH:29]=[O:30]>>[CH2:9]([O:30][CH2:29][C:5](=[CH2:6])[CH2:4][OH:7])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24]

参加物

6

反応物 5

HCID 962WaterHCID 6228Dimethylformamide2 回HCID 82131-BromohexadecaneHCID 24758Sodium hydrideHCID 396052-Butene-1,2-diol

生成物 1

HCID 113588863-Hexadecyloxy-2-methylenepropan-1-ol

実験手順

To 18.5 g of washed sodium hydride in 500 ml of dry dimethylformamide in a water bath is added dropwise, 67.4 g of 2-butene-1,2-diol. A solution of 235 g of hexadecylbromide in 100 ml of dimethylformamide is added dropwise. This mixture is stirred at room temperature for 2 days then poured into water and extracted with ether. The ether extract is separated, dried, evaporated and purified by chromatography, to give 30 g of the desired compound.

後処理

  1. extractionextracted with ether
  2. extractionThe ether extract
  3. customis separated
  4. customdried
  5. customevaporated
  6. custompurified by chromatography

出典と根拠

ORDレコード
ord-ad49c1303dd048139ab41dea53333574
出典データセット
uspto-grants-1993_05
特許番号
US05208223

関連ノート

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