Water → N-[2-(N-methoxyimino)ethyl]phthalimide

HRID 248759

反応式

HRID 248759 の反応式
O=[CH:2][CH2:3][N:4]1[C:8](=[O:9])[C:7]2=[CH:10][CH:11]=[CH:12][CH:13]=[C:6]2[C:5]1=[O:14].Cl.[CH3:16][O:17][NH2:18].C(=O)([O-])[O-].[Na+].[Na+].O>C(O)C>[CH3:16][O:17][N:18]=[CH:2][CH2:3][N:4]1[C:8](=[O:9])[C:7]2=[CH:10][CH:11]=[CH:12][CH:13]=[C:6]2[C:5]1=[O:14]

参加物

6

反応物 4

HCID 962WaterHCID 10340Sodium CarbonateHCID 76201Phthalylglycine aldehydeHCID 521874O-Methylhydroxylamine hydrochloride

生成物 1

HCID 73653097N-[2-(N-methoxyimino)ethyl]phthalimide収率 45.1%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

0.560 g (2.96 mmol) of N-(2-oxoethyl)phthalimide was dissolved in 20 ml of ethanol and to the solution was added 0.330 g (3.95 mmol) of O-methylhydroxylamine hydrochloride. To this suspension was added 10 ml of 0.35M aqueous sodium carbonate solution, followed by being stirred at room temperature for 3 days. The reaction mixture was poured into 100 ml of water and extracted with chloroform (20 ml×3), and the combined organic layer was dried over magnesium sulfate. Chloroform was distilled off and the residual solids were washed with petroleum ether to give 0.291 g (yield 45%) of the titled compound as colorless crystals.

後処理

  1. extractionextracted with chloroform (20 ml×3)
  2. dry with materialthe combined organic layer was dried over magnesium sulfate
  3. distillationChloroform was distilled off
  4. washthe residual solids were washed with petroleum ether

出典と根拠

ORDレコード
ord-92bada989b4c480ea3f3197180ad4955
出典データセット
uspto-grants-1993_05
特許番号
US05211738

関連ノート

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