Hydrochloric Acid → 4,4'-Dichlorobenzhydrol
反応式
[Cl:1][C:2]1[CH:16]=[CH:15][C:5]([C:6]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=2)=[O:7])=[CH:4][CH:3]=1.[BH4-].[Na+].Cl>C(O)(C)C>[Cl:1][C:2]1[CH:16]=[CH:15][C:5]([CH:6]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=2)[OH:7])=[CH:4][CH:3]=1参加物
5
反応条件
- 温度
- 50 °C
実験手順
To a solution of 4,4'-dichlorobenzophenone (2.51 g) in isopropyl alcohol (15 ml) was added sodium borohydride (0.45 g). The mixture was stirred for 4 hours at 50° C. and poured into diluted hydrochloric acid (60 ml). The organic layer was extracted with ethyl acetate (20 ml) and washed with water (30 ml×2). The solution was dried over magnesium sulfate. The solvent was removed in vacuo to give colorless oil of bis(4-chlorophenyl)methanol (2.50 g).
後処理
- extractionThe organic layer was extracted with ethyl acetate (20 ml)
- washwashed with water (30 ml×2)
- dry with materialThe solution was dried over magnesium sulfate
- customThe solvent was removed in vacuo
出典と根拠
- ORDレコード
- ord-1992318223c54782a559e8236f189c69
- 出典データセット
- uspto-grants-1993_05
- 特許番号
- US05212320
反応ノート
読み込み中…