Hydrochloric Acid → 4,4'-Dichlorobenzhydrol

HRID 249166

反応式

HRID 249166 の反応式
[Cl:1][C:2]1[CH:16]=[CH:15][C:5]([C:6]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=2)=[O:7])=[CH:4][CH:3]=1.[BH4-].[Na+].Cl>C(O)(C)C>[Cl:1][C:2]1[CH:16]=[CH:15][C:5]([CH:6]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=2)[OH:7])=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 70344,4'-DichlorobenzophenoneHCID 4311764Sodium borohydride

生成物 1

HCID 70334,4'-Dichlorobenzhydrol収率 98.8%

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

反応条件

温度
50 °C

実験手順

To a solution of 4,4'-dichlorobenzophenone (2.51 g) in isopropyl alcohol (15 ml) was added sodium borohydride (0.45 g). The mixture was stirred for 4 hours at 50° C. and poured into diluted hydrochloric acid (60 ml). The organic layer was extracted with ethyl acetate (20 ml) and washed with water (30 ml×2). The solution was dried over magnesium sulfate. The solvent was removed in vacuo to give colorless oil of bis(4-chlorophenyl)methanol (2.50 g).

後処理

  1. extractionThe organic layer was extracted with ethyl acetate (20 ml)
  2. washwashed with water (30 ml×2)
  3. dry with materialThe solution was dried over magnesium sulfate
  4. customThe solvent was removed in vacuo

出典と根拠

ORDレコード
ord-1992318223c54782a559e8236f189c69
出典データセット
uspto-grants-1993_05
特許番号
US05212320

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