Sodium Hydroxide → Chlorazifop

HRID 249199ノート

反応式

HRID 249199 の反応式
[OH-].[Na+].[Cl:3][C:4]1[C:5]([O:11][C:12]2[CH:25]=[CH:24][C:15]([O:16][CH:17]([CH3:23])[C:18]([O:20]CC)=[O:19])=[CH:14][CH:13]=2)=[N:6][CH:7]=[C:8]([Cl:10])[CH:9]=1>O1CCCC1>[Cl:3][C:4]1[C:5]([O:11][C:12]2[CH:13]=[CH:14][C:15]([O:16][CH:17]([CH3:23])[C:18]([OH:20])=[O:19])=[CH:24][CH:25]=2)=[N:6][CH:7]=[C:8]([Cl:10])[CH:9]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 2829855Propanoic acid, 2-[4-[(3,5-dichloro-2-pyridinyl)oxy]phenoxy]-, ethyl ester

生成物 1

HCID 173715Chlorazifop収率 70%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
52 °C

実験手順

10% Sodium hydroxide solution (170 mL, 0.424 mol) is added to a solution of ethyl 2-{p-[(3,5-dichloro-2-pyridyl)oxy]phenoxy}propionate (79.09 g, 0.212 mol) in tetrahydrofuran with stirring. The reaction mixture is heated to 52° C., stirred for 3 hours, concentrated in vacuo and diluted with water. The aqueous solution is washed with methylene chloride, acidified with concentrated sulfuric acid and extracted with ethyl acetate. The combined organic extracts are dried and concentrated in vacuo to give the title product as a white solid (48.7 g) which is identified by 1H NMR spectral analysis.

後処理

  1. stirringstirred for 3 hours
  2. concentrationconcentrated in vacuo
  3. additiondiluted with water
  4. washThe aqueous solution is washed with methylene chloride
  5. extractionextracted with ethyl acetate
  6. customThe combined organic extracts are dried
  7. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-3ccf186c65be463b818d6c1b2de5565f
出典データセット
uspto-grants-1993_05
特許番号
US05213606

反応ノート

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