Dimethylformamide → 2-{4-[(3,5-Dichloropyridin-2-yl)oxy]phenoxy}propanoyl chloride

HRID 249200ノート

反応式

HRID 249200 の反応式
S(Cl)([Cl:3])=O.[Cl:5][C:6]1[C:7]([O:13][C:14]2[CH:25]=[CH:24][C:17]([O:18][CH:19]([CH3:23])[C:20](O)=[O:21])=[CH:16][CH:15]=2)=[N:8][CH:9]=[C:10]([Cl:12])[CH:11]=1.CN(C)C=O>C(Cl)(Cl)Cl>[Cl:5][C:6]1[C:7]([O:13][C:14]2[CH:25]=[CH:24][C:17]([O:18][CH:19]([CH3:23])[C:20]([Cl:3])=[O:21])=[CH:16][CH:15]=2)=[N:8][CH:9]=[C:10]([Cl:12])[CH:11]=1

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 24386Thionyl ChlorideHCID 173715Chlorazifop

生成物 1

HCID 131894782-{4-[(3,5-Dichloropyridin-2-yl)oxy]phenoxy}propanoyl chloride

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

反応条件

温度
63 °C

実験手順

Thionyl chloride (18.8 mL, 257.1 mmol) is added dropwise to a mixture of 2-{p-[(3,5-dichloro-2-pyridyl)oxy]phenoxy}propionic acid (21.1 g, 64.3 mmol) in chloroform (220 mL). When the addition is complete, dimethylformamide (1.5 mL) is added and the reaction mixture is stirred for 21 hours at 63° C., concentrated in vacuo and chased with chloroform to obtain the title product as a yellow syrup which is identified by 1H NMR spectral analysis.

後処理

  1. additionWhen the addition
  2. concentrationconcentrated in vacuo and chased with chloroform

出典と根拠

ORDレコード
ord-9c29c95b3e804780a4b286297116dea5
出典データセット
uspto-grants-1993_05
特許番号
US05213606

反応ノート

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