2-Methylanisole → 4-Bromo-1-methoxy-2-methylbenzene

HRID 249279

反応式

HRID 249279 の反応式
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][CH3:9].[Br:10]N1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>[Br:10][C:6]1[CH:5]=[CH:4][C:3]([O:8][CH3:9])=[C:2]([CH3:1])[CH:7]=1

参加物

5

反応物 2

HCID 336372-MethylanisoleHCID 67184N-bromobutanimide

生成物 1

HCID 6083154-Bromo-1-methoxy-2-methylbenzene収率 47.1%

試薬・触媒・溶媒 2

HCID 7187Benzoyl Peroxide触媒HCID 5943Carbon Tetrachloride溶媒

実験手順

A solution of 24 g of 2-methylanisole, 35 g of N-bromosuccinimide and 1.24 g of dibenzoyl peroxide in 150 ml of carbon tetrachloride was heated to boiling under reflux for 12 hours. After cooling the solution was filtered and the filtrate is evaporated. The residue was recrystallized from hexane. There were obtained 18.6 g (47%) of 4-bromo-2-methylanisole as a colorless solid; m.p. 66°-68°.

後処理

  1. temperatureunder reflux for 12 hours
  2. temperatureAfter cooling the solution
  3. filtrationwas filtered
  4. customthe filtrate is evaporated
  5. customThe residue was recrystallized from hexane

出典と根拠

ORDレコード
ord-e726e1f3800646a79b1e16dd269c2994
出典データセット
uspto-grants-1993_05
特許番号
US05214046

関連ノート

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