Thionyl Chloride → Pyridine, 3-(2-chloroethyl)-, hydrochloride

HRID 249477ノート

反応式

HRID 249477 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][CH2:8]O)[CH:2]=1.S(Cl)([Cl:12])=O>C(Cl)(Cl)Cl>[ClH:12].[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][CH2:8][Cl:12])[CH:2]=1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 805153-Pyridineethanol

生成物 1

HCID 199465Pyridine, 3-(2-chloroethyl)-, hydrochloride

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

In 100 ml of CHCl3 was dissolved 6.39 g (0.052 mole) of 2-(3-pyridyl)ethanol followed by dropwise addition of 15.6 ml of thionyl chloride with stirring at room temperature. Then, the mixture was stirred for 1.5 hours, after which the solvent was distilled off. After addition of ether, crystals were recovered by filtration and dried. The procedure gave 9.13 g of 2-(3-pyridyl)ethyl chloride hydrochloride as white crystals.

後処理

  1. stirringThen, the mixture was stirred for 1.5 hours
  2. distillationafter which the solvent was distilled off
  3. additionAfter addition of ether, crystals
  4. filtrationwere recovered by filtration
  5. customdried

出典と根拠

ORDレコード
ord-450f1aa5091b42bdb483c6d772a4818a
出典データセット
uspto-grants-1993_05
特許番号
US05214152

反応ノート

読み込み中…