Sodium Chloride → N-Methyl-2-(pyridin-3-YL)ethanamine

HRID 249478

反応式

HRID 249478 の反応式
[CH3:1][NH2:2].Cl.[N:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH2:10][CH2:11]Cl)[CH:5]=1.[OH-].[Na+].[Cl-].[Na+]>>[CH3:1][NH:2][CH2:11][CH2:10][C:6]1[CH:5]=[N:4][CH:9]=[CH:8][CH:7]=1

参加物

5

反応物 4

HCID 5234Sodium ChlorideHCID 6329MethylamineHCID 14798Sodium HydroxideHCID 199465Pyridine, 3-(2-chloroethyl)-, hydrochloride

生成物 1

HCID 5152594N-Methyl-2-(pyridin-3-YL)ethanamine収率 110.5%

反応条件

温度
80 °C

実験手順

To 32.6 g of 40% aqueous methylamine solution was added 7.48 g (0.042 mole) of 2-(3-pyridyl)ethyl chloride hydrochloride in small portions with stirring. The mixture was transfered to a stainless steel reaction column and heated at an external temperature of 80° C. for 4 hours. After cooling, 3.36 g of NaOH was added with ice-cooling and stirring and the mixture was saturated with sodium chloride and extracted with CH2Cl2. The extract was dried over MgSO4 and the CH2Cl2 was distilled off to give 6.32 g of the title compound in crude form as a yellow oil.

後処理

  1. temperatureAfter cooling
  2. temperaturecooling
  3. stirringstirring
  4. extractionextracted with CH2Cl2
  5. dry with materialThe extract was dried over MgSO4
  6. distillationthe CH2Cl2 was distilled off

出典と根拠

ORDレコード
ord-dbb7fe6b4f0c445f834aa9bd274f8366
出典データセット
uspto-grants-1993_05
特許番号
US05214152

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