4-Nitrobenzenesulfonyl chloride → N,N-dimethyl-4-nitrobenzenesulfonamide

HRID 24951

反応式

HRID 24951 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10](Cl)(=[O:12])=[O:11])=[CH:6][CH:5]=1)([O-:3])=[O:2].Cl.[CH3:15][NH:16][CH3:17].C(N(C(C)C)C)(C)C>ClCCl>[CH3:15][N:16]([CH3:17])[S:10]([C:7]1[CH:8]=[CH:9][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=1)(=[O:12])=[O:11]

参加物

5

反応物 3

HCID 74044-Nitrobenzenesulfonyl chlorideHCID 10473Dimethylamine, hydrochlorideHCID 547370N,N-Diisopropylmethylamine

生成物 1

HCID 2747580N,N-dimethyl-4-nitrobenzenesulfonamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

4.43 g (20 mmol) of 4-nitrobenzenesulphonic acid chloride are added dropwise at 0° C. to a solution of 2.45 g (30 mmol) of dimethylamine-hydrochloride and 6.46 g (50 mmol) of N,N-diisopropyl-N-methylamine in 30 ml of dichloromethane. The mixture is stirred for 18 hours at ambient temperature. Then the reaction solution is washed with water and dilute hydrochloric acid, dried over magnesium sulphate and evaporated to dryness.

後処理

  1. washThen the reaction solution is washed with water and dilute hydrochloric acid
  2. dry with materialdried over magnesium sulphate
  3. customevaporated to dryness

出典と根拠

ORDレコード
ord-fa275b5c963c420186aa69e2eb377b96
出典データセット
uspto-grants-2005_02
特許番号
US06855710B2

関連ノート

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