Dimethylformamide → 2-Phenylbutyryl chloride
反応式
S(Cl)([Cl:3])=O.[C:5]1([CH:11]([CH2:15][CH3:16])[C:12](O)=[O:13])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.CN(C=O)C>C(Cl)Cl>[C:5]1([CH:11]([CH2:15][CH3:16])[C:12]([Cl:3])=[O:13])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1参加物
5
実験手順
Thionyl chloride (0.12 mol) in 60 mL of CH2Cl2 was added to a stirred solution of 2-phenylbutyric acid (16.4 g, 0.10 mol). A catalytic amount of DMF was added and the reaction was allowed to continue overnight at room temperature. The volatiles were removed under vacuum and the residual liquid was vacuum distilled to yield 12.4 g (68%) of 2-phenylbutyryl chloride. IR (neat) 1798 cm-1 (C=O).
後処理
- customThe volatiles were removed under vacuum
- distillationdistilled
出典と根拠
- ORDレコード
- ord-27d8209bcb5d425b9dd1ab8a3f96bc9c
- 出典データセット
- uspto-grants-1993_05
- 特許番号
- US05214191
反応ノート
読み込み中…