Dimethylformamide → 2-Phenylbutyryl chloride

HRID 249537

反応式

HRID 249537 の反応式
S(Cl)([Cl:3])=O.[C:5]1([CH:11]([CH2:15][CH3:16])[C:12](O)=[O:13])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.CN(C=O)C>C(Cl)Cl>[C:5]1([CH:11]([CH2:15][CH3:16])[C:12]([Cl:3])=[O:13])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 70122-Phenylbutyric AcidHCID 24386Thionyl Chloride

生成物 1

HCID 981732-Phenylbutyryl chloride収率 68%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Thionyl chloride (0.12 mol) in 60 mL of CH2Cl2 was added to a stirred solution of 2-phenylbutyric acid (16.4 g, 0.10 mol). A catalytic amount of DMF was added and the reaction was allowed to continue overnight at room temperature. The volatiles were removed under vacuum and the residual liquid was vacuum distilled to yield 12.4 g (68%) of 2-phenylbutyryl chloride. IR (neat) 1798 cm-1 (C=O).

後処理

  1. customThe volatiles were removed under vacuum
  2. distillationdistilled

出典と根拠

ORDレコード
ord-27d8209bcb5d425b9dd1ab8a3f96bc9c
出典データセット
uspto-grants-1993_05
特許番号
US05214191

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