Tetrahydrothiophene → 1-(3,3-Dimethyl-2-oxobutyl)thiolan-1-ium bromide

HRID 24968

反応式

HRID 24968 の反応式
[S:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.[Br:6][CH2:7][C:8](=[O:13])[C:9]([CH3:12])([CH3:11])[CH3:10]>C(#N)C>[Br-:6].[O:13]=[C:8]([C:9]([CH3:12])([CH3:11])[CH3:10])[CH2:7][S+:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

4

反応物 2

HCID 1127TetrahydrothiopheneHCID 21642Bromopinacolone

生成物 1

HCID 225645781-(3,3-Dimethyl-2-oxobutyl)thiolan-1-ium bromide収率 80.4%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

Tetrahydrothiophene (11.8 g) was dissolved in 100 ml of acetonitrile, and 20 g of 1-bromo-3,3-dimethyl-2-butanone was slowly added to the above solution. The reaction solution was stirred at room temperature for two days, thereby a powder was precipitated. After adding 100 ml of ethyl acetate to the reaction solution, the powder was filtered out, washed with ethyl acetate and dried, thereby 24 g of 2-oxo-3,3-dimethylbutyltetrahydrothiophenium bromide was obtained.

後処理

  1. customa powder was precipitated
  2. additionAfter adding 100 ml of ethyl acetate to the reaction solution
  3. filtrationthe powder was filtered out
  4. washwashed with ethyl acetate
  5. customdried

出典と根拠

ORDレコード
ord-11e4aee2f6d84e11a6513bca5d39247a
出典データセット
uspto-grants-2005_02
特許番号
US06858370B2

関連ノート

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