Hydrazine → Pyrimidine-4-carbohydrazide

HRID 249780

反応式

HRID 249780 の反応式
[N:1]1[CH:6]=[CH:5][C:4]([C:7]([OH:9])=O)=[N:3][CH:2]=1.C1N=CN(C(N2C=NC=C2)=O)C=1.[NH2:22][NH2:23]>C1COCC1>[N:1]1[CH:6]=[CH:5][C:4]([C:7]([NH:22][NH2:23])=[O:9])=[N:3][CH:2]=1

参加物

5

反応物 3

HCID 9321HydrazineHCID 682631,1'-CarbonyldiimidazoleHCID 1693064-Pyrimidinecarboxylic acid

生成物 1

HCID 468664Pyrimidine-4-carbohydrazide

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of pyrimidine-4-carboxylic acid (1.0 g, 8.0 mmol) in THF (15 mL), N,N-Carbonyldiimidazole (1.4 g, 8.9 mmol) was added. After refluxing for 2 hours, hydrazine (0.8 g, 20 mmol) was added to the reaction mixture slowly with a syringe at 0° C. The reaction mixture was allowed to warm to room temperature slowly and then concentrated to yield the desired product as white solid. LCMS calculated for C5H7N4O (M+H): 139.1. found: 139.1.

後処理

  1. temperatureAfter refluxing for 2 hours
  2. concentrationconcentrated

出典と根拠

ORDレコード
ord-295e910fa0114ff3a389fbb08f41978a
出典データセット
uspto-grants-2011_01
特許番号
US07863285B2

関連ノート

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