Hydrazine → 2-(4-Bromophenoxy)acetohydrazide

HRID 249788

反応式

HRID 249788 の反応式
[Br:1][C:2]1[CH:12]=[CH:11][C:5]([O:6][CH2:7][C:8](O)=[O:9])=[CH:4][CH:3]=1.C1N=CN(C(N2C=NC=C2)=O)C=1.[NH2:25][NH2:26]>C1COCC1>[Br:1][C:2]1[CH:12]=[CH:11][C:5]([O:6][CH2:7][C:8]([NH:25][NH2:26])=[O:9])=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 9321HydrazineHCID 682631,1'-CarbonyldiimidazoleHCID 74657p-Bromophenoxyacetic acid

生成物 1

HCID 6922412-(4-Bromophenoxy)acetohydrazide

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of (4-bromophenoxy)acetic acid (1.0 g, 4.3 mmol) in THF (15 mL) was added N,N-Carbonyldiimidazole (0.84 g, 5.2 mmol). After refluxing for 2 hours, hydrazine (0.6 g, 20 mmol) was added to the reaction mixture slowly with a syringe at 0° C. The reaction mixture was allowed to warm to room temperature slowly and then concentrated to yield the desired product as a white solid. LCMS calculated for C8H10BrN2O2 (M+H): 245.0. found: 244.9, 246.9.

後処理

  1. temperatureAfter refluxing for 2 hours
  2. concentrationconcentrated

出典と根拠

ORDレコード
ord-f0ff9de76d784a37b53ff13824502983
出典データセット
uspto-grants-2011_01
特許番号
US07863285B2

関連ノート

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