1-(Pyridin-2-yl)ethan-1-amine → N-((3-Methylpyridin-2-yl)methyl)-1-(pyridin-2-yl)ethanamine

HRID 251099

反応式

HRID 251099 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH:7]([NH2:9])[CH3:8].[CH3:10][C:11]1[C:12]([CH:17]=O)=[N:13][CH:14]=[CH:15][CH:16]=1.[BH4-].[Na+]>CO>[CH3:10][C:11]1[C:12]([CH2:17][NH:9][CH:7]([C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=2)[CH3:8])=[N:13][CH:14]=[CH:15][CH:16]=1

参加物

5

反応物 3

HCID 5418771-(Pyridin-2-yl)ethan-1-amineHCID 15018743-Methylpyridine-2-carboxaldehydeHCID 4311764Sodium borohydride

生成物 1

HCID 45098009N-((3-Methylpyridin-2-yl)methyl)-1-(pyridin-2-yl)ethanamine収率 60%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Using General Procedure B, reaction of 1-Pyridin-2-yl-ethylamine and 3-methylpyridine-2-carbaldehyde in MeOH with NaBH4 gave (3-Methyl-pyridin-2-ylmethyl)-(1-pyridin-2-ylethyl)-amine as a pale yellow oil (0.21 g, 60%).

出典と根拠

ORDレコード
ord-3adc126131c84145a626891bb65446ca
出典データセット
uspto-grants-2011_01
特許番号
US07863293B2

関連ノート

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