1,1'-Carbonyldiimidazole → N-(1H-Imidazol-2-yl)-1H-imidazole-1-carboxamide

HRID 251134ノート

反応式

HRID 251134 の反応式
S(O)(O)(=O)=O.[NH2:6][C:7]1[NH:8][CH:9]=[CH:10][N:11]=1.[C:12](N1C=CN=C1)([N:14]1[CH:18]=[CH:17][N:16]=[CH:15]1)=[O:13].CCN(C(C)C)C(C)C>C(Cl)Cl>[NH:8]1[CH:9]=[CH:10][N:11]=[C:7]1[NH:6][C:12]([N:14]1[CH:18]=[CH:17][N:16]=[CH:15]1)=[O:13]

参加物

5

反応物 3

HCID 682631,1'-CarbonyldiimidazoleHCID 81531DiisopropylethylamineHCID 135136Bis(2-amino-1H-imidazole) sulphate

生成物 1

HCID 45120888N-(1H-Imidazol-2-yl)-1H-imidazole-1-carboxamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a stirred suspension of 2-aminoimidazole sulfate (667 mg, 5.05 mmol) in CH2Cl2 (25 mL) was added 1,1′-carbonyldiimidazole followed by DIPEA (2.70 mL, 15.50 mmol). The resultant mixture was stirred at room temperature overnight then concentrated under reduced pressure and provided 1.53 g of imidazole-1-carboxylic acid (1H-imidazol-2-yl)-amide as a brown solid.

後処理

  1. concentrationthen concentrated under reduced pressure

出典と根拠

ORDレコード
ord-7a528c5b856746c48612e55ea518b076
出典データセット
uspto-grants-2011_01
特許番号
US07863293B2

反応ノート

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