p-Bromoacetophenone → 2-(4-Bromophenyl)imidazo[1,2-a]pyridine
反応式
[CH3:1][C:2]([C:4]1[CH:9]=[CH:8][C:7]([Br:10])=[CH:6][CH:5]=1)=O.[NH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=1.[OH-].[Na+]>C(O)C>[Br:10][C:7]1[CH:8]=[CH:9][C:4]([C:2]2[N:11]=[C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][N:13]3[CH:1]=2)=[CH:5][CH:6]=1参加物
5
実験手順
Dissolving 15 g (54 mmol) of 4-bromoacetophenone and 5.2 g (55 mmol) of 2-aminopyridine into 100 milliliter of ethanol, adding 7.0 g of sodium hydroxide, the resultant suspension was refluxed under heating for 6 hours. After completion of the reaction, resultant crystals were separated with filtration, washed with water and ethanol, thereby obtaining 12.5 g of 2-(4-bromo-phenyl)-imidazo [1,2-a] pyridine (yield: 85%).
後処理
- temperatureunder heating for 6 hours
- customAfter completion of the reaction
- customresultant crystals were separated with filtration
- washwashed with water and ethanol
出典と根拠
- ORDレコード
- ord-51c6f98e38224fa1b37f06b79058030e
- 出典データセット
- uspto-grants-2011_01
- 特許番号
- US07867629B2
反応ノート
読み込み中…