Cyclopentanone → Pyrrolidine, 1-(1-cyclopenten-1-yl)-

HRID 252034ノート

反応式

HRID 252034 の反応式
[C:1]1(=O)[CH2:5][CH2:4][CH2:3][CH2:2]1.[NH:7]1[CH2:11][CH2:10][CH2:9][CH2:8]1>C1(C)C=CC=CC=1>[C:1]1([N:7]2[CH2:11][CH2:10][CH2:9][CH2:8]2)[CH2:5][CH2:4][CH2:3][CH:2]=1

参加物

4

反応物 2

HCID 8452CyclopentanoneHCID 31268Pyrrolidine

生成物 1

HCID 81570Pyrrolidine, 1-(1-cyclopenten-1-yl)-収率 100%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

To a solution of cyclopentanone (25.0 mL, 0.28 mol. 1.0 eq.) in toluene (100 mL), was added pyrrolidine (27.5 mL, 1.2 eq.). The reaction was equipped with a Dean-Stark and heated at reflux overnight. The reaction mixture was cooled to room temperature and concentrated to give the crude 1-cyclopent-1-enyl-pyrrolidine (45.8 g, >100%).

後処理

  1. customThe reaction was equipped with a Dean-Stark
  2. temperatureheated
  3. temperatureat reflux overnight
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-27383ee5d1b04c0f89eb2268d3003874
出典データセット
uspto-grants-2011_01
特許番号
US07868002B2

反応ノート

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