Trifluoroacetic acid → 3,4-Dichloro-2-fluorophenol

HRID 252162

反応式

HRID 252162 の反応式
FC(F)(F)C(O)=O.[Cl:8][C:9]1[C:10]([F:16])=[C:11]([OH:15])[CH:12]=[CH:13][CH:14]=1.[Cl:17]N1C(=O)CCC1=O>C(#N)C>[Cl:8][C:9]1[C:10]([F:16])=[C:11]([OH:15])[CH:12]=[CH:13][C:14]=1[Cl:17]

参加物

5

反応物 3

HCID 6422Trifluoroacetic acidHCID 31398ChlorosuccinimideHCID 27737123-Chloro-2-fluorophenol

生成物 1

HCID 212741443,4-Dichloro-2-fluorophenol収率 48%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

Trifluoroacetic acid (0.5 mL) was added to a solution of 3-chloro-2-fluorophenol (750 mg, 5.12 mmol) and N-chlorosuccinimide (684 mg, 5.12 mmol) in acetonitrile (30 mL) and the reaction mixture stirred for 24 h. The mixture was concentrated in vacuo and purified by chromatography on silica gel with heptane:EtOAc (9:1, v/v) as eluent to afford the title compound (440 mg, 48%) as a pale yellow solid.

後処理

  1. concentrationThe mixture was concentrated in vacuo
  2. custompurified by chromatography on silica gel with heptane:EtOAc (9:1

出典と根拠

ORDレコード
ord-2b8967049633402ba141b7d6025c334e
出典データセット
uspto-grants-2011_01
特許番号
US07868017B2

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