Water → 5-Fluoro-2-(4'-acetamido-3'-methylphenyl)benzothiazole

HRID 25267

反応式

HRID 25267 の反応式
[C:1](Cl)(=[O:3])[CH3:2].[F:5][C:6]1[CH:7]=[CH:8][C:9]2[S:13][C:12]([C:14]3[CH:19]=[CH:18][C:17]([NH2:20])=[C:16]([CH3:21])[CH:15]=3)=[N:11][C:10]=2[CH:22]=1.C(N(CC)CC)C.O>C(Cl)(Cl)Cl>[F:5][C:6]1[CH:7]=[CH:8][C:9]2[S:13][C:12]([C:14]3[CH:19]=[CH:18][C:17]([NH:20][C:1](=[O:3])[CH3:2])=[C:16]([CH3:21])[CH:15]=3)=[N:11][C:10]=2[CH:22]=1

参加物

6

反応物 4

HCID 962WaterHCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 3968134-(5-Fluoro-1,3-benzothiazol-2-yl)-2-methylaniline

生成物 1

HCID 98827815-Fluoro-2-(4'-acetamido-3'-methylphenyl)benzothiazole

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

Acetyl Chloride (0.09g, 1.55 mmol) was added to a solution of 5-fluoro2-(4′-amino-3′-methylphenyl)benzothiazole (0.2 g, 0.78 mmol) in chloroform (5 ml) containing triethylamine (86 mg, 0.85 mmol). The resulting solution was stirred for 30 min, then poured into water (20 ml). The organic layer was removed, dried (Na2SO4) and evaporated. Recrystallisation from ethanol gave a white solid.

後処理

  1. customThe organic layer was removed
  2. dry with materialdried (Na2SO4)
  3. customevaporated
  4. customRecrystallisation from ethanol
  5. customgave a white solid

出典と根拠

ORDレコード
ord-ae5991969bc04edba7258ddf1b0edf6e
出典データセット
uspto-grants-2005_02
特許番号
US06858633B1

関連ノート

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