Acetone → 3-(3-Amino-4-nitrophenyl)-1-propanol
反応式
[NH2:1][C:2]1[CH:3]=[C:4]([CH2:11][CH2:12][CH:13]=[O:14])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].[BH4-].[Na+].CC(C)=O>O1CCCC1.CC(O)C.C(OCC)(=O)C>[NH2:1][C:2]1[CH:3]=[C:4]([CH2:11][CH2:12][CH2:13][OH:14])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9]参加物
7
反応条件
- 温度
- -5 °C
実験手順
A solution of aldehyde 80 (253 mg, 1.3 mmol) in tetrahydrofurane (1 mL) and propan-2-ol (2 mL) was treated with solid sodium borohydride (175 mg, 4.6 mmol) and stirred at −5° C. for 15 min. Acetone (5 mL) was added, stirred at the same temperature for 10 min and then diluted with ethyl acetate (100 mL), washed with 5% KHSO4 in water, then saturated NaHCO3 and finally with water, dried (MgSO4), and used for the next step without further purification.
後処理
- stirringstirred at the same temperature for 10 min
- washwashed with 5% KHSO4 in water
- dry with materialsaturated NaHCO3 and finally with water, dried (MgSO4)
- customused for the next step without further purification
出典と根拠
- ORDレコード
- ord-17f881df57cc4512903ea2049bcbe2ff
- 出典データセット
- uspto-grants-2011_01
- 特許番号
- US07868205B2
反応ノート
読み込み中…