5-isopropenyl-1H-pyrrolo[2,3-b]pyridine → 5-isopropyl-1H-pyrrolo[2,3-b]pyridine
反応式
[C:1]([C:4]1[CH:5]=[C:6]2[CH:12]=[CH:11][NH:10][C:7]2=[N:8][CH:9]=1)([CH3:3])=[CH2:2]>O1CCCC1.[OH-].[OH-].[Pd+2]>[CH:1]([C:4]1[CH:5]=[C:6]2[CH:12]=[CH:11][NH:10][C:7]2=[N:8][CH:9]=1)([CH3:3])[CH3:2]参加物
4
実験手順
To 5-isopropenyl-1H-pyrrolo[2,3-b]pyridine (10, 0.080 g, 0.501 mmol) in tetrahydrofuran (5.0 mL) was added 20% palladium hydroxide on carbon (5.0 mg). The reaction was stirred under hydrogen at 40 psi for 30 minutes. The reaction mixture was filtered and concentrated to give the compound (11, 0.078 g, 96%). MS (ESI) [M+H+]+=161.
後処理
- filtrationThe reaction mixture was filtered
- concentrationconcentrated
- customto give the compound (11, 0.078 g, 96%)
出典と根拠
- ORDレコード
- ord-87ff7b568543441796a15ec5091015cc
- 出典データセット
- uspto-grants-2011_01
- 特許番号
- US07872018B2
反応ノート
読み込み中…