Sertraline → Sertraline Hydrochloride

HRID 25351

反応式

HRID 25351 の反応式
[CH3:1][NH:2][C@@H:3]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[C@H:6]([C:13]2[CH:14]=[CH:15][C:16]([Cl:20])=[C:17]([Cl:19])[CH:18]=2)[CH2:5][CH2:4]1>C1(C)C=CC=CC=1>[CH3:1][NH:2][C@@H:3]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[C@H:6]([C:13]2[CH:14]=[CH:15][C:16]([Cl:20])=[C:17]([Cl:19])[CH:18]=2)[CH2:5][CH2:4]1.[ClH:19]

参加物

3

反応物 1

HCID 68617Sertraline

生成物 1

HCID 63009Sertraline Hydrochloride

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

Sertraline base (5.8 g) was dissolved in toluene (200 mL). Gaseous hydrochloric acid was bubbled (about pH 1.5) through the solution to induce the formation of sertraline hydrochloride Form XVI. The solution gelled while it was being acidified but remained stirrable. Filtration and drying at 50° C. for 16 hours yields sertraline hydrochloride Form XVI (6.61 gr.).

後処理

  1. customGaseous hydrochloric acid was bubbled (about pH 1.5) through the solution
  2. filtrationFiltration
  3. customdrying at 50° C. for 16 hours

出典と根拠

ORDレコード
ord-9ee4cd5e050c42d7ab043c502bf67170
出典データセット
uspto-grants-2005_02
特許番号
US06858652B2

関連ノート

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