Benzenesulfonyl chloride, 3,4-dichloro- → N-(N-tert-butoxycarbonyl-3-methyl-1H-indazol-5-yl)-3,4-dichlorobenzenesulfonamide

HRID 25388

反応式

HRID 25388 の反応式
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[N:6]=[C:5]2[CH3:18].O1CCCC1.[Cl:24][C:25]1[CH:26]=[C:27]([S:32](Cl)(=[O:34])=[O:33])[CH:28]=[CH:29][C:30]=1[Cl:31]>C(N(CC)CC)C>[C:14]([O:13][C:11]([N:7]1[C:8]2[C:4](=[CH:3][C:2]([NH:1][S:32]([C:27]3[CH:28]=[CH:29][C:30]([Cl:31])=[C:25]([Cl:24])[CH:26]=3)(=[O:34])=[O:33])=[CH:10][CH:9]=2)[C:5]([CH3:18])=[N:6]1)=[O:12])([CH3:15])([CH3:17])[CH3:16]

参加物

5

反応物 3

HCID 7383Benzenesulfonyl chloride, 3,4-dichloro-HCID 8028TetrahydrofuranHCID 59276571tert-Butyl 5-amino-3-methyl-1H-indazole-1-carboxylate

生成物 1

HCID 22567170N-(N-tert-butoxycarbonyl-3-methyl-1H-indazol-5-yl)-3,4-dichlorobenzenesulfonamide収率 43.4%

試薬・触媒・溶媒 1

HCID 8471Triethylamine溶媒

実験手順

N-(N-tert-Butoxycarbonyl-3-methyl-1H-indazol-5-yl)-3,4-dichlorobenzenesulfonamide can be obtained as described in Example 1 from 1 g of 5-amino-N-tert-butoxycarbonyl-3-methyl-1H-indazole, 50 ml of tetrahydrofuran, 1.15 ml of triethylamine and 1.1 g of 3,4-dichlorobenzenesulfonyl chloride. 0.8 g of N-(N-tert-butoxycarbonyl-3-methyl-1H-indazol-5-yl)-3,4-dichlorobenzenesulfonamide is thus obtained in the form of a white solid melting at 171° C.

出典と根拠

ORDレコード
ord-4989f77d96a64fd1bef6fc477d954100
出典データセット
uspto-grants-2005_02
特許番号
US06858638B2

関連ノート

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