Pyridine → N-(3-amino-1H-indazol-5-yl)-2,6-difluorobenzenesulfonamide

HRID 25400

反応式

HRID 25400 の反応式
[NH2:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([NH2:11])[CH:9]=2)[NH:4][N:3]=1.N1C=CC=CC=1.[F:18][C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([F:25])[C:20]=1[S:26](Cl)(=[O:28])=[O:27]>O1CCCC1>[NH2:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([NH:11][S:26]([C:20]3[C:21]([F:25])=[CH:22][CH:23]=[CH:24][C:19]=3[F:18])(=[O:28])=[O:27])[CH:9]=2)[NH:4][N:3]=1

参加物

5

反応物 3

HCID 1049PyridineHCID 27342712,6-Difluorobenzenesulfonyl chlorideHCID 177237271H-Indazole-3,5-diamine

生成物 1

HCID 22567087N-(3-amino-1H-indazol-5-yl)-2,6-difluorobenzenesulfonamide収率 8.4%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

N-(3-Amino-1H-indazol-5-yl)-2,6-difluorobenzenesulfonamide can be obtained as described in Example 39 from 1 g of 3,5-diamino-1H-indazole, 10 ml of pyridine, 10 ml of tetrahydrofuran and 1.4 g of 2,6-difluorobenzenesulfonyl chloride. 179 mg of N-(3-amino-1H-indazol-5-yl)-2,6-difluorobenzenesulfonamide are thus obtained in the form of a gray solid melting at 241° C. (analysis C13H10F2N4O2S % calculated C, 48.15; H, 3.11; F, 11.72; N, 17.28; O, 9.87; S, 9.89. % found C, 47.81; H, 3.18; F, 11.64; N, 17.00; S, 9.67).

出典と根拠

ORDレコード
ord-1a290df78f194a468dfcbf0c96e7c4cf
出典データセット
uspto-grants-2005_02
特許番号
US06858638B2

関連ノート

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