Pyridine → N-(3-amino-1H-indazol-5-yl)-2,6-dichlorobenzenesulfonamide

HRID 25401

反応式

HRID 25401 の反応式
[NH2:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([NH2:11])[CH:9]=2)[NH:4][N:3]=1.N1C=CC=CC=1.[Cl:18][C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([Cl:25])[C:20]=1[S:26](Cl)(=[O:28])=[O:27]>O1CCCC1>[NH2:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([NH:11][S:26]([C:20]3[C:21]([Cl:25])=[CH:22][CH:23]=[CH:24][C:19]=3[Cl:18])(=[O:28])=[O:27])[CH:9]=2)[NH:4][N:3]=1

参加物

5

反応物 3

HCID 1049PyridineHCID 5221832,6-DichlorobenzenesulfonylchlorideHCID 177237271H-Indazole-3,5-diamine

生成物 1

HCID 22567053N-(3-amino-1H-indazol-5-yl)-2,6-dichlorobenzenesulfonamide収率 18.6%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

N-(3-Amino-1H-indazol-5-yl)-2,6-dichlorobenzenesulfonamide can be obtained as described in Example 39 from 0.8 g of 3,5-diamino-1H-indazole, 8 ml of pyridine, 8 ml of tetrahydrofuran and 1.29 g of 2,6-dichlorobenzenesulfonyl chloride. 350 mg of N-(3-amino-1H-indazol-5-yl)-2,6-dichlorobenzenesulfonamide are thus obtained in the form of a pale yellow solid melting at 250° C. (analysis C13H10Cl2N4O2S % calculated C, 43.71; H, 2.82; Cl, 19.85; N, 15.68; O, 8.96; S, 8.98. % found C, 43.39; H, 2.92; Cl, 19.45; N, 15.31; S, 8.73).

出典と根拠

ORDレコード
ord-cef4ef310be94a4899347406ec1fd4e5
出典データセット
uspto-grants-2005_02
特許番号
US06858638B2

関連ノート

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