Triethylamine → HCID 178490666、化合物

HRID 254626ノート

反応式

HRID 254626 の反応式
[C:1]([C:5]1[S:9][C:8](=[NH:10])[N:7]([CH2:11][C:12]2([OH:18])[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]2)[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[Cl:19][C:20]1[CH:21]=[CH:22][C:23]([O:29][CH3:30])=[C:24]([CH:28]=1)[C:25](O)=[O:26].S(Cl)(Cl)=O.C(N(CC)CC)C>C1COCC1>[C:1]([C:5]1[S:9]/[C:8](=[N:10]\[C:25](=[O:26])[C:24]2[CH:28]=[C:20]([Cl:19])[CH:21]=[CH:22][C:23]=2[O:29][CH3:30])/[N:7]([CH2:11][C:12]2([OH:18])[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17]2)[CH:6]=1)([CH3:4])([CH3:2])[CH3:3]

参加物

6

反応物 4

HCID 8471TriethylamineHCID 24386Thionyl ChlorideHCID 769705-Chloro-o-anisic acidHCID 668518251-((5-tert-butyl-2-iminothiazol-3(2H)-yl)methyl)cyclohexanol

生成物 1

HCID 178490666HCID 178490666、化合物収率 51.4%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

The product of Example 20A (1.3 g, 3.7 mmol), 5-chloro-2-methoxybenzoic acid (0.70 g, 3.7 mmol), thionyl chloride (10 mL) and triethylamine (1.6 mL, 11 mmol) in THF (25 mL) were processed as described in Example 18B and Example 18C to provide the title compound (0.82 g, 1.9 mmol, 50% yield). MS (DCI/NH3) m/z 437 (M+H)+.

出典と根拠

ORDレコード
ord-ec2b8adfa7e344f6ac99834959cb9697
出典データセット
uspto-grants-2011_01
特許番号
US07875640B2

反応ノート

読み込み中…