Oxalyl chloride → 3,4-Difluorophenylacetyl chloride
反応式
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=O)[CH:5]=[CH:6][C:7]=1[F:8].C(Cl)(=O)C([Cl:16])=O>O1CCCC1.CN(C)C=O>[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([Cl:16])=[O:12])[CH:5]=[CH:6][C:7]=1[F:8]参加物
5
実験手順
To a solution of 3,4-difluorophenylacetic acid (10.24 g, 60.4 mmol) in tetrahydrofuran (200 mL) and dimethylformamide (5 drops) at room temperature was added in 1 mL portions oxalyl chloride (11 mL, 126 mmol). The reaction mixture was stirred 2 hours at room temperature and concentrated to an orange liquid that was used directly in the next step.
後処理
- concentrationconcentrated to an orange liquid that
出典と根拠
- ORDレコード
- ord-7bc715ea766044878ccdcc925405a241
- 出典データセット
- uspto-grants-2005_02
- 特許番号
- US06858739B2
反応ノート
読み込み中…