Oxalyl chloride → Hexahydro-2,5-methano-pentalene-3a-carbonyl chloride

HRID 255050

反応式

HRID 255050 の反応式
[CH2:1]1[CH:8]2[C:4]3([C:10]([OH:12])=O)[CH2:5][CH:6]([CH2:9][CH:2]1[CH2:3]3)[CH2:7]2.C(Cl)(=O)C([Cl:16])=O>ClCCl>[CH2:1]1[CH:8]2[C:4]3([C:10]([Cl:16])=[O:12])[CH2:5][CH:6]([CH2:9][CH:2]1[CH2:3]3)[CH2:7]2

参加物

4

反応物 2

HCID 65578Oxalyl chlorideHCID 2733865Hexahydro-2,5-methanopentalene-3a(1H)-carboxylic acid

生成物 1

HCID 13182402Hexahydro-2,5-methano-pentalene-3a-carbonyl chloride収率 99.3%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of commercially available hexahydro-2,5-methano-pentalene-3a-carboxylic acid (10 g, 0.06 mol) in dichloromethane (200 mL) was added oxalyl chloride (8.7 g, 0.066 mol). The mixture was stirred overnight and then concentrated under reduced pressure to afford the title compound as a colorless oil (11 g, 99%). MS (DCI/NH3) m/z 184 (M+H)+.

後処理

  1. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-82faefc782d147d88966d283fa9acab9
出典データセット
uspto-grants-2011_01
特許番号
US07875639B2

関連ノート

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