Citric Acid → Benzyl 2-methylaziridine-1-carboxylate

HRID 255457

反応式

HRID 255457 の反応式
[CH3:1][CH:2]1[CH2:4][NH:3]1.C(N(CC)CC)C.[CH2:12]([O:19][C:20](Cl)=[O:21])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.C(O)(=O)CC(CC(O)=O)(C(O)=O)O>C(Cl)Cl>[C:20]([N:3]1[CH2:4][CH:2]1[CH3:1])([O:19][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:21]

参加物

6

反応物 4

HCID 311Citric AcidHCID 63772-MethylaziridineHCID 8471TriethylamineHCID 10387Benzyl chloroformate

生成物 1

HCID 21895246Benzyl 2-methylaziridine-1-carboxylate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

2-Methyl aziridine is dissolved in CH2Cl2 and triethylamine under argon at 0° C. Benzylchloroformate is added and the contents of the flask are at room temperature overnight. The mixture is poured into 10% citric acid and is extracted with CHCl3. The organic layer is washed with dilute aqueous NaHCO3 and dried over MgSO4. The solution is evaporated to yield N-Cbz-2-methyl aziridine.

後処理

  1. customat 0° C
  2. extractionis extracted with CHCl3
  3. washThe organic layer is washed with dilute aqueous NaHCO3
  4. dry with materialdried over MgSO4
  5. customThe solution is evaporated

出典と根拠

ORDレコード
ord-1a4e7089217245829b297700e2f626b8
出典データセット
uspto-grants-1987_10
特許番号
US04698231

関連ノート

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