Dimethylformamide → 3-(2-Methyl-thiazol-4-yl)-phenylamine

HRID 255900

反応式

HRID 255900 の反応式
Br.[NH2:2][C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][CH:12]=1)[C:6](=O)[CH2:7]Br.[C:13]([NH2:16])(=[S:15])[CH3:14].CN(C)C=O.[OH-].[Na+]>O>[CH3:14][C:13]1[S:15][CH:7]=[C:6]([C:5]2[CH:10]=[CH:11][CH:12]=[C:3]([NH2:2])[CH:4]=2)[N:16]=1

参加物

6

反応物 4

HCID 6228DimethylformamideHCID 14798Sodium HydroxideHCID 2723949ThioacetamideHCID 201651043-Amino-phenacyl bromide hydrobromide

生成物 1

HCID 7365353-(2-Methyl-thiazol-4-yl)-phenylamine収率 79%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 3-amino-phenacyl bromide hydrobromide (11.78 g), thioacetamide (3 g) and dimethylformamide (20 ml) was stirred at room temperature for 24 hours and then poured into water (100 ml). The resulting solution was made alkaline with 10% sodium hydroxide, and the precipitate was filtered off and dried to give 6 g of 2-methyl-4-(3-amino-phenyl)-thiazole; M.p. 134°-137° C.

後処理

  1. filtrationthe precipitate was filtered off
  2. customdried

出典と根拠

ORDレコード
ord-6884dac1deb44f1293e4f4875b0ec887
出典データセット
uspto-grants-1987_10
特許番号
US04699915

関連ノート

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