Monobasic potassium phosphate → Ribavirin

反応式

[NH:1]1C=CN=N1.[C@@H:6]1([N:15]2C3N=C[N:21]=[C:19]([OH:20])[C:18]=3[N:17]=[CH:16]2)[O:14][C@H:11]([CH2:12][OH:13])[C@@H:9]([OH:10])[C@H:7]1[OH:8].P([O-])(O)(O)=O.[K+]>>[CH:16]1[N:15]([C@@H:6]2[O:14][C@H:11]([CH2:12][OH:13])[C@@H:9]([OH:10])[C@H:7]2[OH:8])[N:1]=[C:18]([C:19]([NH2:21])=[O:20])[N:17]=1

参加物

反応物 3

HCID 516951Monobasic potassium phosphate

HCID 178418936HCID 178418936、化合物

HCID 178521066(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-hydroxypurin-9-yl)oxolane-3,4-diol

生成物 1

HCID 37542Ribavirin

実験手順

By using a substrate solution (pH 6.0) containing 40 mM triazole as the base donor, 60 mM inosine as the saccharide residue donor and 40 mM potassium dihydrogenphosphate, reactions were carried out in the same manner as in Example 1 at respective reaction temperature (40° to 70° C.) for 24 hours to produce ribavirin. The results are shown in Table 8.

出典と根拠

ORDレコード: ord-ad34d5e319f442798901411e2fa06cde
出典データセット: uspto-grants-1993_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05258301

反応ノート

読み込み中…

参加物