Water → 3-(3-(3-Pentynyloxy)-1,2,5-thiadiazol-4-yl)pyridine
反応式
[CH2:1]([OH:6])[CH2:2][C:3]#[C:4][CH3:5].[H-].[Na+].Cl[C:10]1[C:11]([C:15]2[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=2)=[N:12][S:13][N:14]=1.O>O1CCCC1>[CH2:1]([O:6][C:10]1[C:11]([C:15]2[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=2)=[N:12][S:13][N:14]=1)[CH2:2][C:3]#[C:4][CH3:5]参加物
6
実験手順
To a solution of 3-pentyn-1-ol (750 mg, 9 mmol) and sodium hydride (310 mg, 9 mmol) in dry tetrahydrofuran was added a solution of 3-(4-chloro-1,2,5-thiadiazol-3-yl)pyridine (590 mg, 3 mmol) in dry tetrahydrofuran. The reaction mixture was stirred at room temperature for 1 h. Water was added and the mixture was extracted with ether. The ether phase was dried and evaporated to give the title compound.
後処理
- extractionthe mixture was extracted with ether
- dry with materialThe ether phase was dried
- customevaporated
出典と根拠
- ORDレコード
- ord-155419b9b0ac400fbd6ca017b2484a4e
- 出典データセット
- uspto-grants-1993_11
- 特許番号
- US05260311
反応ノート
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