Sodium Hydroxide → 2-((Benzyloxy)methyl)morpholine

HRID 257278

反応式

HRID 257278 の反応式
S(O)([O:4][CH2:5][CH2:6][NH2:7])(=O)=O.[OH-].[Na+].[CH2:11]([O:18][CH2:19][CH:20]1[CH2:22]O1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>CO>[CH2:11]([O:18][CH2:19][CH:20]1[O:4][CH2:5][CH2:6][NH:7][CH2:22]1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

参加物

5

反応物 3

HCID 14798Sodium Hydroxide2 回HCID 70223Aminoethyl sulfateHCID 94247Benzyl glycidyl ether

生成物 1

HCID 136700222-((Benzyloxy)methyl)morpholine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
50 °C

実験手順

199 g of 2-aminoethyl hydrogen sulfate are added to 164 ml of 70% sodium hydroxide solution, the solution is heated to 50° C. and added dropwise to a solution of (RS)-benzyloxymethyloxirane in 280 ml of methanol. After 1 hour at 50° C. a further 280 ml of 70% sodium hydroxide solution are added thereto and the solution is stirred overnight. Then, the reaction mixture is poured on to ice and extracted with toluene. The organic phase is washed with water, dried and evaporated. After distillation there are obtained 26.8 g of rac-2-benzyloxymethylmorpholine, MS: M+ -91=116 (benzyl).

後処理

  1. additionThen, the reaction mixture is poured on to ice
  2. extractionextracted with toluene
  3. washThe organic phase is washed with water
  4. customdried
  5. customevaporated
  6. distillationAfter distillation

出典と根拠

ORDレコード
ord-1e506a4d26304ae08c89fe3fcd0bbae1
出典データセット
uspto-grants-1993_11
特許番号
US05260307

関連ノート

読み込み中…