Iodoethane → 1-Phenyl-3-(3-n-propyl-4-pyridyl)butane

HRID 257474

反応式

HRID 257474 の反応式
[C:1]1([CH2:7][CH2:8][CH:9]([C:11]2[CH:16]=[CH:15][N:14]=[CH:13][C:12]=2[CH3:17])[CH3:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:18](I)[CH3:19].[Li].C(NC(C)C)(C)C>>[C:1]1([CH2:7][CH2:8][CH:9]([C:11]2[CH:16]=[CH:15][N:14]=[CH:13][C:12]=2[CH2:17][CH2:18][CH3:19])[CH3:10])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

4

反応物 3

HCID 6340IodoethaneHCID 197832971-Phenyl-3-(3-methyl-4-pyridyl)butaneHCID 45051747Lithium diisopropylamine

生成物 1

HCID 197833201-Phenyl-3-(3-n-propyl-4-pyridyl)butane収率 15.6%

実験手順

2.1 g (9.35 mmol) of 1-phenyl-3-(3-methyl-4-pyridyl)butane, 1.46 g (9.35 mmol) of ethyl iodide and 2 equivalent of lithium-diisopropylamine were reacted in the same manner as in Example 1. The reaction product was purified to obtain 0.37 g of the desired compound (yield: 15.6%).

後処理

  1. customThe reaction product was purified

出典と根拠

ORDレコード
ord-050c0500979a4433a4718a4be18e859c
出典データセット
uspto-grants-1993_11
特許番号
US05262420

関連ノート

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