(2-Bromoethyl)cyclohexane → 4-{1-[(2E)-but-2-en-1-yloxy]ethyl}-6-(2-methoxyphenyl)-2,2-dimethyl-1,2-dihydroquinoline

HRID 25787

反応式

C(OC(N1C2C(=CC(C3C=CC=CC=3OC)=CC=2)C(C(O)C)=CC1(C)C)=O)(C)(C)C.[CH:31]1([CH2:37][CH2:38][O:39][CH:40]([C:42]2[C:51]3[C:46](=[CH:47][CH:48]=[C:49]([C:52]4[CH:57]=[CH:56][CH:55]=[CH:54][C:53]=4[O:58][CH3:59])[CH:50]=3)[NH:45][C:44]([CH3:61])([CH3:60])[CH:43]=2)[CH3:41])CCCC[CH2:32]1.C[Si]([N-][Si](C)(C)C)(C)C.[Na+].C1(CCBr)CCCCC1>C1COCC1>[CH2:38]([O:39][CH:40]([C:42]1[C:51]2[C:46](=[CH:47][CH:48]=[C:49]([C:52]3[CH:57]=[CH:56][CH:55]=[CH:54][C:53]=3[O:58][CH3:59])[CH:50]=2)[NH:45][C:44]([CH3:61])([CH3:60])[CH:43]=1)[CH3:41])/[CH:37]=[CH:31]/[CH3:32]

参加物

実験手順

4-[1-(2-Cyclohexylethoxy)ethyl]-6-(2-methoxyphenyl)-2,2-dimethyl-1,2-dihydroquinoline 4-(1-Hydroxyethyl)-6-(2-methoxyphenyl)-2,2-dimethyl-2H-quinoline-1-carboxylic acid tert-butyl ester (70 mg) was treated with 255 μL of 1 M solution of sodium bis(trimethylsilyl)amide in THF and 49 mg of 2-cyclohexylethyl bromide to give the alkylated product, which was deprotected to yield 31 mg of title compound as an oil.

後処理

customto give the alkylated product, which

出典と根拠

ORDレコード: ord-ce9a7ee077a34850b30661c174215de3
出典データセット: uspto-grants-2005_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06858627B2

反応式

参加物

反応物 3

生成物 1

試薬・触媒・溶媒 1

実験手順

後処理

出典と根拠

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